A strategy for identifying target-specific leads by screening libraries composed of small, low molecular weight molecules and subject them to cycles of synthetic elaborations.
Our FBDD approach will be presented by our partner György M Keserű, research professor, RCNS Hungary, at the 8th RSC-BMCS Fragment-based Drug Discovery Meeting conference in Cambridge and the Drug Discovery Chemistry conference in San Diego.
Find a description of our approach in our newly published white paper:
“Lead Discovery for Hot Spots – FBDD by Smart Fragment Libraries and Expanded Chemical Space”
To view the full publication in Nature Communications entitled Exploring protein hotspots by optimized fragment pharmacophores - Associated Paper from Nature Communications
To learn more - Summary in Chemistry Community