Fragment-To-Lead

A strategy for identifying target-specific leads by screening libraries composed of small, low molecular weight molecules and subject them to cycles of synthetic elaborations.

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Our FBDD approach will be presented by our partner György M Keserű, research professor, RCNS Hungary, at the 8th RSC-BMCS Fragment-based Drug Discovery Meeting conference in Cambridge and the Drug Discovery Chemistry conference in San Diego.

Find a description of our approach in our newly published white paper:

“Lead Discovery for Hot Spots – FBDD by Smart Fragment Libraries and Expanded Chemical Space

To view the full publication in Nature Communications entitled Exploring protein hotspots by optimized fragment pharmacophores - Associated Paper from Nature Communications

To learn more - Summary in Chemistry Community


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