CFL: A Proprietary Next Generation Fragment Library
The Comprehensive Fragment Library (CFL) is a set of small, low flexibility, medicinally interesting fragments. This library originates from a starting set of >3 million potentially synthesizable virtual fragments designed from first principles to maximize exploration of target interactions. Extensive 3D clustering analysis allows broad coverage of chemistry space and provides an immediate follow-up strategy from any screening hit.
CFL designed for maximum diversity with med chem friendly properties
Characteristics
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Diverse collection of rigid, low molecular weight fragments designed from first principles
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Designed using our team’s deep medicinal chemistry expertise to meet very strict property criteria
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Enables access to ~ 3 million high value fragments with less than 19 heavy atoms
Unique 3D enabled diversity fragment screening set
Benefits
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Break out of the 2D world with new chemical matter
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Choose from thousands of related virtual alternatives for each fragment hit
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Gain a head start on hit to lead and IP
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Access novel, 3D structures even from commercial hits
