A strategy for identifying target-specific leads by screening libraries composed of small, low molecular weight molecules and subject them to cycles of synthetic elaborations.


Our FBDD approach will be presented by our partner György M Keserű, research professor, RCNS Hungary, at the EFMC International Symposium on Medicinal Chemistry.

Find a description of our approach in our newly published white paper:

“Lead Discovery for Hot Spots – FBDD by Smart Fragment Libraries and Expanded Chemical Space

To view the full publication in Nature Communications entitled Exploring protein hotspots by optimized fragment pharmacophores - Associated Paper from Nature Communications

To learn more - Summary in Chemistry Community

Engage with Fragment-To-Lead

Area of interest: